Wildcats made a decent enough start and went 6-0 up with a Jamie Rooney try, converted by Danny Brough.
But Harlequins made the most of some pretty poor Wakefield defending to notch four tries in ten minutes to storm into a 20-6 lead by the 21st minute - an advantage they held up to half-time.
Danny Orr, Matt Gafa, Michael Worrincy and Ricki Sheriffe touched down on the back of exceptional balls skills from the visitors, but - and this proved crucial in the long run - goalkicker Rob Purdham managed to convert only two from the four attempts.
Richard Moore got the Sky TV pundit's man of the match vote. But what did you think. Click here and let us know.That said, Harlequins were good value for their 20-6 half-time lead.
Wakefield came out for the second half full of verve and fire - led by prop Richard Moore and playmakers Sam Obst, Danny Brough and Jamie Rooney.
And 50 minutes after opening the scoring, Rooney bagged his second try, converted by Brough to cut the gap to just eight points.
Wakefield were back in the match and when Tony Martin touched down five minutes later - put in by Rooney after a defence-splitting kick from Brough - Harlequins looked decidedly rocky.
Twelve minutes from time Sam Obst dodged and squirmed his way over the line to level and Brough converted to nose his side in front.
Five minutes later Wakefield had a penalty shot when Howell followed through on kicker Rooney - and Brough made no mistake from 20-odd metres out from a tightish angle.
Harlequins threw everything at Wakefield in the closing minutes and it needed a desperate cover tackle from live-wire Tevita Leo-Latu on Tony Clubb to deny the visitors a last-gasp equaliser.
More on this match in Friday's Wakefield Express.
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