Glen Chapple claimed his 900th first-class wicket for Lancashire but the Red Rose cricketers left it late to restrain Warwickshire on the second day of their LV= County Championship meeting at Old Trafford.
When dismissing Varun Chopra for 52 immediately before lunch on Monday, 40-year-old Chapple became the 15th player to reach the landmark haul for the county - Jack Simmons was the last man to do so.
But Chapple, who made his Lancashire debut in 1992, had to wait for the result of his lbw appeal against the visiting batsman before he could celebrate properly.
Umpire Peter Hartley gave him the nod and Warwickshire took lunch having reached 144 for two.
Chapple later removed Ateeq Javid (25), while Simon Kerrigan had Will Porterfield - who at one point carted a six off James Anderson into a neighbouring construction site - caught on 77 and Tom Smith claimed Laurie Evans’ wicket for 17, but Lancashire’s attack toiled for most of the afternoon.
Warwickshire surpassed their hosts’ first-innings total of 247 all out thanks to Ian Bell, who put on 75 runs off 162 balls - including eight fours and a six.
The home attack could not make any further headway until Smith had Chris Woakes caught behind by new boy Jos Buttler - his first catch for Lancashire - and Wayne White bowled Bell out before promptly dismissing Jeetan Patel.
The New Zealand international edged White’s delivery to Buttler for only two runs.
Smith would strike once again before stumps, trapping Chris Wright lbw to register bowling figures of four for 67.
Keith Barker and Oliver Hannon-Dalby added 25 more runs between them before bad light in Manchester forced an early finish to day two, with Warwickshire on 319 for nine and taking a 69-run lead into the third day.
The match is Lancashire’s last under the supervision of 2011 Championship-winning coach Peter Moores, who was announced as former England boss Andy Flower’s successor on Saturday morning.