The retailer currently operates two stores in the city, at Trinity Walk Shopping Centre and Cathedral Retail Park.
Though the Cathedral Retail Park stores has remained open for much of the pandemic, the Trinity Walk branch has been closed since the start of lockdown in March 2020.
Last year, Sainsbury's, which owns the retailer, confirmed plans to close 420 Argos across the UK, but said it would open 150 outlets in the larger Sainsbury's stores.
And the supermarket chain has now confirmed that it will close both of its Wakefield branches in the coming months, to make way for a new store inside the Trinity Walk superstore.
Those employed at the two closing stores will be offered "opportunities to redeploy" within the company, a spokesperson confirmed.
The full Sainsbury's statement read: “Later this year a brand new Argos store will open inside Sainsbury’s Wakefield Marsh Way.
"By bringing together the much-loved brands of Sainsbury’s and Argos under the one roof, our customers will be able to enjoy greater convenience as the new Argos will enable them to purchase thousands of technology, home and toy products while picking up their groceries.
“As a result of this change, our Argos Trinity Walk and Argos Wakefield Cathedral Retail Park stores will close and colleagues are being offered opportunities to redeploy to alternative roles within Sainsbury’s.”