Officers raided the property on Oakes Street, off Flanshaw Lane, this morning at about 7.15am, although it is thought nobody was at home.
A man and woman in their 30s have been arrested following searches across Heckmondwike and Dewsbury
They are believed to be part of an organised crime group linked to a number of substantial seizures of heroin since October 2020 at Heathrow Airport.
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A further property in the Heckmondwike area was searched, along with a house in Birstall and the one in Wakefield.
One of the properties is linked to a second man who is wanted in connection to the same conspiracy and is believed to no longer be in the UK.
Officers attending the searches recovered quantities of drugs likely to be cocaine and heroin, as well as drugs paraphernalia and thousands of pounds in cash.
Both the man and the woman remain in custody for further questioning. Searches at the properties are ongoing.
NCA Operations Manager Nigel Coles, said: “The drugs trade fuels violence, ruins lives and can devastate communities.
“These arrests are part of an ongoing investigation and shows the NCA’s commitment to tackling the trade in Class A drugs from source to consumer.”