The Castleford team had triumphed 38-24 at Leigh, but went down 36-28 in the return after having bounced back from 12 points down to lead 22-18 early in the second period.
The Miners, though, went eight points clear when Joe Connor and Adam Thomason steamed in. And although Lane got back into the frame with a Danny Sowerby try on 74 minutes, plus Nathan Fozzard’s fourth goal, Leigh sealed a win that keeps them clear of the drop-zone with a last-gasp touchdown for Noah Lancelott and Sam Pilkington landing his sixth goal from as many attempts.
Andrew Badrock, with a brace, and Lancelott had crossed in the first half for the Miners, while Lane had led through tries by Lewis Price, Rob Matomosi (twice) and Connor McGrath.
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Lock Lane slipped down to fifth with this defeat and are at home again this Saturday when they take on Wath Brow Hornets, who are one place above them.