A Red Honda jazz and a Mercedes Sprinter were involved in the incident close to the junction of Bleakley Lane and Notton Lane, close to the village of Notton.
The 22-year-old driver of the Sprinter was airflifted to Leeds General Infirmary.
Emergency services were called just before 11.45am and the road was reopened at 4pm today (Monday).
A woman driving the Honda was not injured.