The Cantate Domino sculpture will go under the hammer at Bonhams in London in November.
The sculpture, which was acquired from Leeds City Art Gallery’s 1958 exhibition, will be sold alongside work by other big names in modern British art.
Other art includes a Laurence Stephen Lowry painting, called A Street in Clitheroe.
The 1961 painting is expected to fetch between £80,000 and £120,000.
All of the art has come from the Barbara and Arnold Burton Collection.
Leeds-born philanthropist Mr Burton was a motor sport enthusiast and was the youngest son of the founder of one of Britain’s biggest tailoring manufacturers, which grew to become the Burton Group.
His wife Barbara Flatau attended Les Beaux Arts in Paris and was a regular at London galleries.