The festival is a chance for comic book fans to dress up like their favourite characters and pick up collectables.
And businesses will each have their own theme during the event on Saturday, July 4.
The Six Chimneys on Kirkgate will see its staff dress up as zombies from the hit television series The Walking Dead.
The pub will have face painting and games throughout the day followed by zombie-themed food and cocktails during the evening.
Team leader Beth Latham said: “We are expecting lots of people from outside the city to come as comic-con is such a popular event.”
And The Empire will invade Trinity Walk Shopping Centre from 11am to 3pm.
Darth Vader and a stormtrooper will patrol Trinity Walk and those brave enough can have their picture taken with the dark lord.
Cormac Hamilton, centre manager at Trinity Walk said: “It is going to be a great day celebrating all things comics.”
And retailers will be selling action figures, autographs and much more at Unity Works from 10am to 5pm.
Red Dwarf’s Arnold Rimmer, played by Chris Barrie, Robert Llewellyn, who starred as Kryten, and Hattie Hayridge, who played Holly, will be at the venue.
Doctor Who stars Colin Baker and Nicola Bryant, who played the doctor’s former companion Peri Brown, will also meet and greet with fans.
The venues and their themes are:
l Ridings Shopping Centre – Teenage Mutant Ninja Turtles
l Santander – Doctor Who
l Trinity Walk – Star Wars
l Six Chimneys – Zombies
l Black Horse – Heroes
l Unity Works – X Men
l Havanna bar – Heroes
l Mex Bar – Terminator
l Fanny and Bacardi – Heroes as never seen before
l Tequila Bar – Heroes
l X Bar – Star Trek
l Pizza Express – Star Wars
l Boomerang – Spider-man
l Reflex/Flares – Superman
l Coco Bongo – X Men
l Holiday Inn – Heroes
l Reflections – Batman
l Qudos – Villains
l Bannisters – Doctor Who
l Jocks Cavern – Avengers
l The Gate – Teenage Mutant Ninja Turtles