The incident has happened eastbound between Junction 28 at Tingley and Junction 29 at Lofthouse.
The female driver has got out of the car unassisted and is said to have no major injuries.
No other car were involved in the crash, which happened in the outside lane
Police and an ambulance are at the scene.
There is congestion on the M62 and on the A650 Bradford Road in Tingley between Blackgates School and the M62 Junction 28 roundabout junction.