Last year the retailer confirmed plans to take over the unit which previously housed Wakefield's Homebase store at the Beck Retail Park.
The Ings Road unit has stood empty since Homebase store ceased trading in January.
The new store will create 80 jobs for the city.
It will be the 170th branch of the British retailer to open across the UK and Ireland.
Police release images of man wanted in connection with serious assault at Wakefield pub
Crack-addicted shop robber claimed pal borrowed his clothing
Castleford shop where police seized 8,000 illegal cigarettes could have its licence revoked over fears of ‘serious organised crime’
Residents split on new art installation at City Fields
Heartless thieves steal £600 watches from Wakefield Hospice charity shop
Firm founder Chris Dawson said: “Each store plays an important part in the success of our company and Wakefield is no exception.
"This site has been on the radar for some time and we are delighted to replace the former Homebase with a new national retailer in the town.
He added: “We are very lucky with the staff we have and I look forward to welcoming the new team members to the company. I would like to invite the local community to join us for the opening next week and discover the fantastic selection of products that we offer.”