The incident happened yesterday, Sunday, August 18 on the A614 at Driffield at 4.30pm.
It involved a VW Polo and a Kawasaki motorbike.
The woman, who was riding pillion on the bike, died at the scene.
The man who was riding the motorbike sustained serious but non-life-threatening injuries. The driver of the car was unhurt.
Jack Kirmond murder: Man charged as family pays tribute to 'amazing son, fiance, brother and friend'
Village pub owner plans to return The Libb in Ryhill to its ‘former glory’ after 300 residents backed licence victory
Police release images of man wanted in connection with serious assault at Wakefield pub
Tributes flood in for Wakefield murder victim Jack Kirmond
‘Living like battery chickens’: Residents launch campaign to stop former Wakefield fish shop being turned into house for 17 people
Humberside Police are appealing for witnesses to the crash or anyone who may have seen either vehicle beforehand. Contact them in 101 quoting log 441 of 18/08/19.